PLOS

The remains of domesticated crop plants at an archaeological site in southwest Amazonia supports the idea that this was an important region in the early history of crop cultivation, according to a study published July 25, 2018 in the open-access journal PLOS ONE by Jennifer Watling from the Museum of Archaeology and Ethnology at the University of…

Scientists have developed a novel computational approach that incorporates individual patients’ brain activity to calculate optimal, personalized brain stimulation treatment for Alzheimer’s disease. Lazaro Sanchez-Rodriguez of the University of Calgary, Canada, and colleagues present their new framework in PLOS Computational Biology. Electrical stimulation of certain parts of the brain could help promote healthy activity in neural…

Micro-grippers may be able to navigate unstructured environments and could help reduce risk during surgeries, according to a study published December 13, 2017 in the open-access journal PLOS ONE by Federico Ongaro from the University of Twente, The Netherlands and colleagues. Microrobotic technologies such as micro-grippers could potentially help grasp and manipulate objects in unstructured microscopic environments.…

Sea-level rise may impact vast numbers of archaeological and historic sites, cemeteries, and landscapes on the Atlantic and Gulf coasts of the southeastern United States, according to a study published November 29, 2017 in the open-access journal PLOS ONE by David Anderson from the University of Tennessee, Knoxville, USA, and colleagues. To estimate the impact…

From 2006 through 2011, Nepal conducted a mass immunization campaign against Japanese encephalitis–a mosquito-borne viral disease. Now, investigators have reported in PLOS Neglected Tropical Diseasesthat the vaccination effort prevented thousands of cases of Japanese encephalitis (JE) and cut JE rates in Nepal by at least 78%. In many Asian countries, JE is associated with significant mortality;…

New genome sequences shed light on both the origins of the tardigrades (also known as water bears or moss piglets), and the genes that underlie their extraordinary ability to survive in extreme conditions. A team of researchers led by Mark Blaxter and Kazuharu Arakawa from the universities of Edinburgh, Scotland and Keio, Japan respectively, have…

An analytical tool that combines Google search data with government-provided clinical data can quickly and accurately track dengue fever in less-developed countries, according to new research published in PLOS Computational Biology by Shihao Yang of Harvard University and colleagues. The research builds on a methodology previously developed by the team to track influenza in the United States.…

Scientists have identified thousands of previously ignored genetic mutations that, although rare, likely contribute to cancer growth. The findings, which could help pave the way to new treatments, are published in PLOS Computational Biology. Cancer arises when genetic mutations in a cell cause abnormal growth that leads to a tumor. Some cancer drugs exploit this to…

A team of researchers has used a computational modeling approach to analyze and compare the toxic effects of fifteen different drugs on the liver, according to a study in PLOS Computational Biology. Drugs prescribed for various medical conditions can cause harmful liver side effects. Lab experiments with liver cells can help reveal the underlying molecular mechanisms…

The complexity of neural networks makes them difficult to analyze, but manmade computing systems should be simpler to understand. In a study published in PLOS Computational Biology, researchers applied widely used neuroscience approaches to analyze the classic games console Atari 2600 – which runs the videogame “Donkey Kong” – and found that such approaches do not…

Scientists have found potential evidence of Ebola virus replication in the lungs of a person recovering from infection, according to new research published in PLOS Pathogens. The findings could aid research into new treatment approaches and better understanding of how the virus is transmitted. From 2013 to 2016, West Africa experienced an unprecedented outbreak of hemorrhagic…

Two potential biofuel crops in Hawaii–sugarcane and napiergrass–may sequester more carbon in soil than is lost to the atmosphere, according to a study published January 4, 2017 in the open-access journal PLOS ONE by Meghan Pawlowski from University of Hawaii Manoa, U.S., and colleagues. From a climate change perspective, replacing fossil fuel with biofuel makes sense only…

The highly consistent anatomical patterning found in the brain’s cortex is controlled by genetic factors, reports a new study by an international research consortium led by Chi-Hua Chen of the University of California, San Diego, and Nicholas Schork of the J. Craig Venter Institute, published on July 26 in PLOS Genetics. The human brain’s wrinkled cerebral…

Scientists use mathematical modeling to simulate human mesenchymal stem cell delivery to a damaged heart and found that using one sub-set of these stem cells minimises the risks associated with this therapy. The study, published in PLOS Computational Biology, represents a development in novel strategies to repair and regenerate heart muscle and could improve stem cell…